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Owensboro is the industrial and cultural hub of western Kentucky. Located along the southern banks of the Ohio River, Owensboro is the fourth largest city in terms of population in the Commonwealth of Kentucky.

Owensboro is located 32 miles southeast of Evansville, Indiana; 123 miles north of Nashville, Tennessee; 109 miles southwest of Louisville, Kentucky; 203 miles southeast of St. Louis, Missouri; and 205 miles southwest of Cincinnati, Ohio.